Emdogain is made from an enamel matrix derivative secreted from Hertwig’s epithelial sheath during porcine tooth development. This enamel matrix derivative contains amelogenin as its major component in addition to other enamel matrix proteins such as enamelins, tuftelin, amelin, and ameloblastin. It serves as an important regulator of enamel mineralization and plays an important role during periodontal tissue formation,and also stimulates the regeneration of periodontal tissues including the acellular cementum, periodontal ligament fibers and alveolar bone by mimicking tooth development.
REF: JOE - 34, (1), 2008
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