casein phospopeptide-amorphous calcium phosphate (CPP-ACP)

 Casein phosphopeptides (CPP) stabilize high concentrations of calcium and phosphate ions, together with fluoride ions, at the tooth surface by binding to pellicle and plaque. Although the calcium, phosphate and fluoride ions are stabilized by the CPP from promoting dental calculus, the ions are freely bioavailable to diffuse down concentration gradients into enamel subsurface lesions thereby effectively promoting remineralization.

CPP containing the cluster sequence –Ser(P)-Ser(P)-Ser(P)-Glu-Glu- stabilize ACP(amorphous calcium phosphate) in metastable solution. Through the cluster sequence the CPP bind to forming nanoclusters of ACP preventing their growth to the critical size required for nucleation and phase transformation.

CPP-ACP forms nanocomplexes and bound tightly to Streptococcus mutans and plaque to produce a reservoir of bioavailable calcium ions.

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CPP-ACP promotes the inhibition of enamel demineralization and enhance remineralization through the localization of bioavailable calcium and phosphate ions at the tooth surface.

can be used for incipient caries and for dentinal hypersensitvity.......... commercially available as  GC TOOTH MOUSE and  RECALDENT  

                                                               

REF: Australian Dental Journal 2008; 53: 268–273