MTAD ( mixture of tetracycline acid detergent )

MTAD( mixture of tetracycline acid detergent ) is a solution composed of citric acid, doxycycline, and Tween 80, a detergent. It has been introduced by Torabinejad et al. and is marketed as Biopure (Dentsply, Tulsa, USA). it removes  smear layer adequately and have superior antimicrobial efficacy. The cytotoxicity of MTAD in vitro has been shown to be lower than eugenol, 3% hydrogen peroxide, calcium hydroxide, 5.25% NaOCl, CHX, and EDTA

                                        REF: Endodontic Topics 2009, 16, 27–63