CALCIUM HYDROXIDE ( antibacterial activity and mineralisation mechanism )

1. Calcium hydroxide is antibacterial depending on the availability of free hydroxyl ions .
2. Denaturation of proteins ,DNA break down and lipidic peroxidation are main actions responsible for antimicrobial activity of calcium hydroxide
3. It has a very high p11 (hydroxyl group) that encourages repair and active calcification. There is an initial degenerative response in the immediate vicinity followed rapidly by a mineralization and ossification response .
4. The alkaline pH of calcium hydroxide neutralizes lactic acid from osteoclasts and prevents dissolution of mineralized components of teeth. This pH also activates alkaline phosphatase that plays an important role in hard tissue formation .
5. Calcium hydroxide activates the calcium-dependent adenosine triphosphatase reaction associated with hard tissue formation .

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                                                                                    REF: JOE, 2009, 35 (4)