Bisphosphonates (BPs) are widely used drugs for patients with bone disorders showing increased osteoclast activity, such as Paget’s disease, hypercalcemia of malignancy, and osteoporosis.
Depending on the content of BPs in molecular level, BPs can be divided into
NON-NITROGEN CONTAINING BPs, such as clodronate, etidronate, tiludronate.
NITROGEN- CONTAINING BPs, such as alendronate, pamidronate, risedronate, and zoledronate.
There have been many studies investigating the use of BPs during dental trauma mainly focusing on the use of alendronate and etidronate by means of topical root treatment and intracanal agents. Topical application of alendronate has been shown to decrease root apex inflammation and inhibited root resorption in delayed replanted animal teeth.
REF: Dental Traurnatologv ,26,2010.
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